Diabetes: Injectable Insulin Treatment – Lose a Leg and Gain Possible Coma

by Thomas McGregor and Amy Gaines


Insulin Routines

  • Insulin is required for people with type 1 diabetes and sometimes necessary for people with type 2 diabetes.
  • The syringe is the most common form of insulin delivery, but there are other options, including insulin pens and pumps.
  • Insulin should be injected in the same general area of the body for consistency, but not the exact same place.
  • Insulin delivery should be timed with meals to effectively process the glucose entering your system.

With the help of your health care team, you can find an insulin routine that will keep your blood glucose near normal, help you feel good, and fit your lifestyle.

Type 1

People diagnosed with type 1 diabetes usually start with two injections of insulin per day of two different types of insulin and generally progress to three or four injections per day of insulin of different types. The types of insulin used to depend on their blood glucose levels. Studies have shown that three or four injections of insulin a day give the best blood glucose control and can prevent or delay the eye, kidney, and nerve damage caused by diabetes.

Type 2

Most people with type 2 diabetes may need one injection per day without any diabetes pills. Some may need a single injection of insulin in the evening (at supper or bedtime) along with diabetes pills. Sometimes diabetes pills stop working, and people with type 2 diabetes will start with two injections per day of two different types of insulin. They may progress to three or four injections of insulin per day.

Studies Concerning Pharmaceutical Treatment of Diabetes

Compiled by researchers from the U.K., the new study involved carefully scrutinizing the safety of insulin injections in order to gain a more thorough understanding of the treatment’s many possible side effects. Utilizing data from the U.K. General Practice Research Database, which included nearly 85,000 patients with Type II diabetes, researchers compared the side effects of insulin injections alone with four other common treatment protocols for the disease.

In the study the conclusion cited as follows: “The primary aim of diabetes management is the achievement and maintenance of normoglycemia. The importance of glucose control in reducing vascular outcomes is well known.” Something to notice about this statement is that the researchers are most interested in the management and maintenance of diabetes versus a cure. This results in the entire study being more about how to manage versus cure diabetes, which implies a continuation of the diabetic condition.

Myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck, or jaw. Often it occurs in the center or left side of the chest and lasts for more than a few minutes. The discomfort may occasionally feel like heartburn. Other symptoms may include shortness of breath, nausea, feeling faint, a cold sweat, or feeling tired. About 30% of people have atypical symptoms. Women more often have atypical symptoms than men. Among those over 75 years old, about 5% have had an MI with little or no history of symptoms. An MI may cause heart failure, an irregular heartbeat, cardiogenic shock, or cardiac arrest. Metformin suppressed the liver into producing and releasing less sugar. 

Compared to metformin monotherapy, sulfonylurea monotherapy, metformin plus sulfonylurea combination therapy, and insulin plus metformin combination therapy, insulin monotherapy was found to increase the risk of both stroke and cancer by about 43 percent, and major adverse cardiac events by about 74 percent. And while the risk of myocardial infarction almost doubles while on insulin monotherapy, a risk of neuropathy more than doubles, according to the figures. Metformin is a hydrochloride (a chemical complex composed of an organic base (such as an alkaloid) in association with hydrogen chloride). Chemistry, a hydrochloride is an acid salt resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base. An alternative name is chlorhydrate, which comes from French.

Endogenous means originating within the body, and exogenous means originating outside the body. Health professionals who treat people with diabetes often apply these terms to insulin: Endogenous insulin refers to the insulin the pancreas makes, and exogenous insulin refers to the insulin people inject or infuse via an insulin pump.

Sulfonylureas are a class of organic compounds used in medicine and agriculture. They are antidiabetic drugs widely used in the management of diabetes mellitus type 2. They act by increasing insulin release from the beta cells in the pancreas. A number of sulfonylureas are also used as herbicides (“weedkiller”) because they can interfere with plant biosynthesis of certain amino acids.

Being in a phenotypically different subgroup: Phenotypically is an observable physical or biochemical characteristic of an individual, as determined by both genetic makeup and environmental influences.  When you are placed in a subgroup, you are placed with a different or distinct group within a group; a subdivision of the main group.

Fact: 60% of the world’s type 2 diabetics live in Asia due to a high level of grains consumed in the typical Asian diet. 

In a CBS Miami report, takers of Metformin were willing to pay higher co-pays for a supplemental drug Invokana regardless of the increased risk of side effects. Same takers of the Metformin drug cited stomach and energy level issues when taking it. Invokana is an add-on in addition to Metformin and therein increases the risk of side effects. Additionally, Invokana (Johnson & Johnson) has had major litigation challenges since the side effects of the drug have become increasingly evident. In May 2017, the FDA issued another safety warning indicating that Invokana could increase the risk of leg and foot amputations. According to the FDA, between the launch of Invokana in March 2013 and June 6, 2014, the agency received at least 20 adverse event reports of users of SGLT2(The sodium/glucose cotransporter 2  is a protein that in humans is encoded by the SLC5A2(solute carrier family 5 (sodium/glucose cotransporter)) gene. SGLT2 is a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. SGLT2 is the major cotransporter involved in glucose reabsorption in the kidney.) inhibitors, or kidney failure, suffering ketoacidosis. These resulted in hospitalization or the need for emergency room visits in every case. The FDA reported that it has continued to receive adverse event reports of similar problems since that time, and the agency is investigating the potential side effects of Invokana and related diabetes treatments. Although Invokana works by inhibiting kidney function, and several experts have suggested that the drug makers knew or should have known about the risk of kidney problems from Invokana, potential failure to warn claims are being reviewed for individuals who have suffered kidney failure after using the type 2 diabetes drug. In September 2015, the FDA issued a safety warning indicating that Invokana may increase the risk of bone fractures.

Victoza

Victoza slows down digestion which “makes you feel fuller, longer” This does not treat the root cause, which is the decision on what you eat. What Victozaoza does is try to force you into not eating less by biochemical manipulation, not controlling what your lifestyle choices.

On May 17, 2015, in a Fox New report Dr. Mar Siegal cited that pharmaceuticals like Metformin and Janovia preserve a hormone called incretin. Dr. Siegal said that “Incretin is a hormone that is a precursor to insulin. Our body is trying to get rid of incretin all the time – that particular hormone and, Janovia keeps it around.” Wouldn’t seem logical that if the body is naturally attempting to get rid of the incretin in the body and, that taking a drug with noted side-effects that will keep the hormone around, is technically a toxic idea? Dr. Siegal went on to say that even if you aren’t that heavy but, are binge eating all the time that Janovia can help with that. Yes, you read that correctly. (Dr. Marc Siegel is an American physician, Fox News medical correspondent)

Bottom Line

These pharmaceutical drugs are by prescription only.

If you don’t want to change your lifestyle to something more healthy, you will still pay with the vast array of side-effects that these drugs hold in-store for you. Furthermore, stacking pharmaceuticals only increases your chances for drastic side-effects with the possibility of death.

The choice is yours.

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RESOURCES CITED:

 

 

 

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